Intravenous immunoglobulin (IVIG) is pooled human IgG that is presumed to alter the immune system by various mechanisms (also see page 41). A small, randomized trial testing the efficacy of adding IVIG to IVMP in the treatment of relapses was performed in the Netherlands. A beneficial effect of IVIG could not be demonstrated.

In the opinion of the Committee, IVIG should not be added to IVMP in patients with an acute exacerbation.