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[2008 updates are highlighted in red]
| Description: |
People with MS are prone to sleep disorders. Valerian, a herb that has been used for more than 1,000 years, may be helpful for treating insomnia. |
| Rationale: |
The mechanism by which valerian might produce its actions is unclear. It may involve an effect on an anxiety- and sleep-related neurochemical known as GABA (gamma-aminobutyric acid).
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| Evaluation: |
Several clinical studies indicate that valerian is possibly effective for treating insomnia. Since these studies have been of variable quality, further studies are needed. Valerian is also sometimes claimed to be an effective therapy for depression, insomnia, and muscle stiffness (spasticity). However, due to limited clinical studies, its effects on these conditions are uncertain. |
| Risks: |
Valerian is generally safe. It may cause sedation, which may worsen MS fatigue or increase the sedating effects of some medications. The safety of long-term use and use during pregnancy or breastfeeding has not been established. |
| Costs: |
Valerian is inexpensive. |
| Committee opinion: |
In the opinion of the Committee, valerian is a low-cost, generally well-tolerated therapy that may be effective for treating insomnia. |
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