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| | Levels of Evidence | | Principle | 1a | 1b | 2a | 2b | 3 | 4 | | 1.1 | | | | | 22 | 9 | | 1.2 | | | | 1 | 8 | 10 | | 1.3 | | | | | 3 | 4 | | 1.4 | | | | | 6 | 1 | | 1.5 | | 3 | | 2 | 24 | 15 | | 1.6 | | | | | 9 | 7 | | 2.1.1 | | | | | 5 | 2 | | 2.1.2 | 1 | 9 | 2 | 9 | 17 | 43 | | 2.2.1 | | | | 4 | 6 | 9 | | 2.2.2 | | | | | 4 | 8 | | 2.3.1 | | | | | 4 | 15 | | 2.3.2 | | 7 | 2 | 5 | 11 | 41 | | 2.3.3 | | | | 1 | 1 | 1 | | 2.3.4 | | | | | 3 | 5 | | 2.3.5 | | | | | 7 | 6 | | 2.3.6 | | 3 | 2 | 4 | 11 | 10 | | 2.4.1 | | 6 | 1 | 8 | 18 | 43 | | 3.1 | | 1 | | | 6 | 6 | | 3.2 | | | | | 3 | 4 | | 3.3* | | | | | | | | 4.1 | | 6 | | 3 | 11 | 16 | | 4.2 | | 5 | | 1 | 8 | 21 | | 4.3 | | | | | 4 | 5 | | 5.1 | | | | 1 | 24 | 10 | | 5.2 | | | | 1 | 7 | 4 | | 5.3 | | | | 1 | 18 | 8 | | 5.4 | | | | 1 | 23 | 12 | | 5.5 | | | | 1 | 5 | 6 | | 5.6 | | | | 1 | 2 | 2 | | 6.1 | | | | | 4 | 4 | | 6.2 | | | | | 2 | 2 | | 7.1 | | | | | 17 | 14 | | 7.2 | | | | | 16 | 12 | | 7.3 | | | | | 6 | 2 | | 7.4 | | | | | 9 | 9 | | 7.5 | | | | | 6 | 2 | | 8.1 | | | | | 2 | 2 | | 8.2 | | | | | 5 | 2 | | 8.3 | | | | | 3 | 2 | | 9.1 | | | | | 2 | | | 9.2* | | | | | | | | 9.3* | | | | | | | | 10.1.1 | | | | | 5 | 3 | | 10.1.2 | | | | | 3 | | | 10.1.3 | | | | | 4 | | | 10.2.1 | | | | | 3 | | | 10.2.2 | | | | | 3 | | | | * Evidence provided by the expert opinion of the interviewees and Oversight Group members listed in Acknowledgments. |
1a Meta-analysis of
randomized controlled trials
1b Randomized controlled trial
2a Controlled study, without randomization
2b Quasi-experimental study
3 Non-experimental,descriptive study (e.g.,comparative study, correlation study,case study)
4 Expert committee eport, opinion and/or experience of respected authority
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