This UK study looked at a new MR image-processing method, ADvanced
Image Algebra (ADIMA), which uses conventional proton density-weighted
and T2 weighted images to assess white matter heterogeneity. The white
matter lesions were classified into two groups: bright (ADIMA-b) and
dark (ADIMA-d), with different quantitative MR properties, which can be
Results from the study showed that ADIMA-b exhibited
higher T1 and T2, and lower MTR that the T2 white matter lesions (WML).
The values between ADIMA-b and T1-WML, were similar but only partially
overlapping. Also, ADIMA-d showed quantitative characteristics similar
to T2-WML but they were only partially overlapping. Therefore, ADIMA
allows the simple classification of white matter lesions, which likely
reflects pathological heterogeneity.
Authors: Yiannakas MC, Tozer DJ, Schmierer K
Source: Mult Scler. 2012 Oct 4. [Epub ahead of print]
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