In this prospective study, they analysed the clinical, radiological
and genetic characteristics of a series of 23 patients presenting with
inflammatory longitudinally extensive transverse myelitis (LETM).
Results showed that there was a predominance of middle-age females with
moderate-severe disability at onset (48% unable to walk). 50% of them
had an almost complete recovery with minimal disability, EDSS ≤2.5,
after a median follow up of 32 months. Over this time, one patient
converted to MS, two had relapsing LETM with NMO-IgG and 20 remained as
idiopathic with relapses in 4 of these. They found an overrepresentation
of the genotype HLA-DRB1*13 in LETM patients compared with control, MS
and NMO patients. The EDSS at onset was predictive of the final outcome
and only 3 of the patients remained wheel-chair dependent.
Authors: Sepúlveda M, Blanco Y, Rovira A
Source: Mult Scler. 2012 Oct 4. [Epub ahead of print]
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