Analysis of prognostic factors associated with longitudinally extensive transverse myelitis

In this prospective study, they analysed the clinical, radiological and genetic characteristics of a series of 23 patients presenting with inflammatory longitudinally extensive transverse myelitis (LETM). Results showed that there was a predominance of middle-age females with moderate-severe disability at onset (48% unable to walk). 50% of them had an almost complete recovery with minimal disability, EDSS ≤2.5, after a median follow up of 32 months. Over this time, one patient converted to MS, two had relapsing LETM with NMO-IgG and 20 remained as idiopathic with relapses in 4 of these. They found an overrepresentation of the genotype HLA-DRB1*13 in LETM patients compared with control, MS and NMO patients. The EDSS at onset was predictive of the final outcome and only 3 of the patients remained wheel-chair dependent.

Authors: Sepúlveda M, Blanco Y, Rovira A

Source:
Mult Scler. 2012 Oct 4. [Epub ahead of print]

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