Association between multiple sclerosis risk-associated SNPs and relapse and disability - a prospective cohort study

This study from Australia investigated if known MS risk-associated single-nucleotide polymorphisms (SNPs) were associated with clinical course and if these SNPs modified the 25(OH)D-relapse association. The study included a prospective cohort of 141 participants with RRMS.

Results showed that five SNPs were associated with relapse, with significant cumulative genotype risk effects and two demonstrated significant allele dose-response. Two SNPs altered the 25(OH)D-relapse association with significant allele dose-response. Five SNPs changed levels of 25(OH)D, with significant cumulative genotype risk effect. There was no evidence of an association between SNPs and disability. Overall, this study shows an association between known MS risk-associated SNPs and relapse. Therefore, this demonstrates a gene-environment interaction which is likely to influence MS clinical course and supports the role of vitamin D in MS relapse.

Authors: Lin R, Taylor BV
Source: Mult Scler. 2013 Jul 25. [Epub ahead of print]

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