The authors from Sweden looked at brain atrophy as a manifestation of tissue damage in MS, using synthetic tissue mapping (SyMap). The brain parenchymal fraction (BPF) was automatically calculated based on the absolute quantification of the tissue relaxation rates and the proton attenuation. This method is relatively fast with an acquisition time of under six minutes and a postprocessing time of under two minutes.
A significant difference in mean brain parenchymal fraction between patients with MS and controls was observed as well as a linear relationship between BPF and age, disease duration and Expanded Disability Status Scale.
Authors: Vågberg M, Lindqvist T, Ambarki K, Warntjes JB, Sundström P, Birgander R, Svenningsson A
Source: AJNR Am J Neuroradiol. 2012 Sep 13. [Epub ahead of print]
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