Cerebral white matter blood flow and energy metabolism in multiple sclerosis

In this study, the researchers looked at the relationship between reduced normal-appearing white matter (NAWM) cerebral blood flow (CBF) as well as axonal mitochondrial metabolism (looking at N-acetylaspartate/creatine (NAA/Cr) ratios) and astrocytic phosphocreatine (PCr) metabolism.

In 10 healthy controls and 25 MS patients, they measured CBF using pseudo-continuous arterial spin labelling. NAA/Cr was measured using (1) H-MR spectroscopy and PCr/β-ATP ratios using (31) P-MR spectroscopy in the centrum semiovale.

Overall, the results showed that there was no correlation between CBF and PCr/ β-ATP. CBF and NAA/Cr correlated in controls but not in MS patients. Compared to controls, NAA/Cr in NAWM of the centrum semiovale of MS subjects was decreased, while PCr/ β-ATP was increased. Therefore, there was no relationship between CBF in NAWM and impaired axonal mitochondrial metabolism or astrocytic PCr metabolism.

Authors: Steen C, D'haeseleer M, Hoogduin JM
Source: Mult Scler. 2013 Feb 21. [Epub ahead of print]

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