Clinically meaningful performance benchmarks in MS: timed 25-foot walk and the real world



This cross-sectional study looked at characterising the clinical meaningfulness of the Timed 25-Foot Walk (T25FW) benchmarks in 159 MS patients.

The T25FWT was associated with real-life anchors, functional independence and physiologic measurements of gait and disease progression.

The candidate T25FW benchmarks were then prospectively validated in 95 subjects using 13 measures of ambulation, cognition, patient-reported outcomes and optical coherence tomography. In subjects that had a T25FW of 6 to 7.99 seconds, it was associated with a change in occupation due to MS, occupational disability, walking with a cane and needing help with instrumental activities of daily living.

While those with a T25FW of
≥8 was associated with collecting supplemental security income and government health care, walking with a walker and patients were unable to do instrumental activities of daily living. This study demonstrates two clinically meaningful T25FW benchmarks of ≥6 seconds and ≥8 seconds.

Further studies are needed to confirm the clinical relevance of these suggested T25FW benchmarks and to see if there are additional benchmarks in those <6 seconds and those >10 seconds.

Authors: Goldman MD, Motl RW

Source: Neurology. 2013 Oct 30. [Epub ahead of print]


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