Combined visual and motor evoked potentials predict multiple sclerosis disability after 20 years

The role of combined evoked potentials (EP) was investigated in 28 MS patients to see if the EP measures enabled prediction of MS disability after 20 years.

Combined motor and visual evoked potentials were recorded at entry (T0), six months (T1), 12 months (T2) and 24 months (T3). A brain MRI was performed at T0 and T2, while EDSS was recorded at baseline and then again at year 14 (T4) and year 20 (T5).

Results showed that the z-transformed EP latencies correlated with EDSS at T5 as well as the change in EDSS from T0 to T5. Neither EDSS at T0, nor T2-lesion, nor gadolinium-enhancing lesion quantities at T0 improved prediction of EDSS at T5.

These results support a role for combined EPs in detection of patients at risk for long-term unfavourable clinical evolution in MS.

Authors: Schlaeger R, Schindler C
Source: Mult Scler. 2014 Feb 26. [Epub ahead of print]
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