Cortical plasticity predicts recovery from relapse in multiple sclerosis



This study from Italy looked at the hypothesis that synaptic plasticity, mainly long-term potentiation (LTP), may be a substrate for compensating the clinical defect that results from the incomplete repair of neuronal damage.

Based on this, the researchers looked at the correlation between a measure of LTP, that is paired associative stimulation (PAS), at the time of relapse and symptom recovery in 22 patients with newly diagnosed MS.

The results from this study showed that PAS-induced LTP was normal in patients with complete recovery, while it was reduced in patients with partial or absent recovery 12 weeks after the relapse onset. Based on this, synaptic plasticity may contribute to symptom recovery after relapse in MS and PAS measured during a relapse may be used as a predictor of recovery.

Authors: Mori F, Kusayanagi H
Source: Mult Scler. 2013 Nov 21. [Epub ahead of print]
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