Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis
Micro(mi)RNAs are a class of small non-coding RNAs that have recently been discovered to be regulatory modulators of gene expression post-transcriptionally. Mutations of miRNAs have been linked to autoimmune diseases including MS.
This study investigated free circulating miRNAs in the plasma of MS patients compared to controls.
The results showed that there were altered levels of cell-free miR-15b, miR-23a and miR-223 in MS patients. There was a direct correlation between miRNA levels and EDSS. The researchers hypothesise that the down regulation of miRNA may result in over-expression of target genes involved in MS.
Based on this, miRNA profiling could potentially identify disease biomarkers in MS.
: Fenoglio C, Ridolfi E
: Mult Scler. 2013 Dec;19(14):1938-42. doi: 10.1177/1352458513485654.
Read the abstract