Latest MS research news

Latest MS research news | 05 February 2013

Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride

This interesting pilot study looked at the neuroprotective effects of amiloride in patients with primary progressive MS.

From MSIF

Latest MS research news | 29 January 2013

Tumefactive demyelination: an approach to diagnosis and management

This review article looks at tumefactive demyelination and proposes an approach to diagnosis and management. Tumefactive demyelinating (TD) lesions are larger than those seen in typical MS (>2cm) and may occur in individuals either with or without established MS.

From MSIF

Latest MS research news | 29 January 2013

Renal deterioration in multiple sclerosis patients with neurovesical dysfunction

This research group looked at the prevalence of renal ultrasound (RUS) abnormalities over time in people with MS with lower urinary tract symptoms (LUTS).

From MSIF

Latest MS research news | 29 January 2013

Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment

This review article from the US looks at the pathogenesis of MS which they propose involves the modulation of cellular mechanisms regulating gene expression, based on the integration of epidemiological data, genome-wide association studies and reports of neuroimaging abnormalities in clinically unaffected individuals.

From MSIF

Latest MS research news | 22 January 2013

Impaired social cognition in multiple sclerosis

This study from Germany explored if theory of mind impairments in MS can be detected using the video based Movie for the Assessment of Social Cognition and whether impaired social cognition can occur independently of deficits in memory, processing speed or executive function in this patient population.

From MSIF

Latest MS research news | 22 January 2013

Load-dependent dysfunction of the putamen during attentional processing in patients with clinically isolated syndrome suggestive of multiple sclerosis

The researchers from Italy looked at functional MRI (fMRI) patterns of the brain in clinically isolated syndrome (CIS) patients during the performance of attention tasks using the Variable Attentional Control (VAC) task.

From MSIF

Latest MS research news | 22 January 2013

Spinal cord quantitative MRI discriminates between disability levels in multiple sclerosis

This study looked at quantitative diffusion tensor and magnetisation transfer imaging measures in the spinal cord to assess lesion burden with high and low disability. 124 people with MS underwent 3-T cervical spinal cord MRI.

From MSIF

Latest MS research news | 14 January 2013

Multiple Sclerosis: Validation of MR Imaging for Quantification and Detection of Iron

This study from Canada evaluated four MR imaging methods based on transverse relaxation (T2 weighted, 2 mapping, and R2* mapping) and phase imaging, for measuring iron in subcortical grey matter and for detecting iron within and surrounding MS lesions.

From MSIF

Latest MS research news | 14 January 2013

On the sex ratio of multiple sclerosis

This review article looks at the female-to-male ratio of MS, which is similar to other immune-mediated diseases, with the susceptibility higher in females than males.

From MSIF

Latest MS research news | 14 January 2013

Clinical effects of natalizumab on multiple sclerosis appear early in treatment course

The researchers looked at when the clinical effects of natalizumab become apparent in a phase II study, and the annualised relapse rates per 3-month period, and the time to first relapse in the phase III AFFIRM study and in the multinational Tysabri Observational Program.

From MSIF
 

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Atacicept in multiple sclerosis: a randomised, placebo-controlled, double-blind, phase 2 trial