Latest MS research news

Latest MS research news | 13 November 2013

Risk genes associated with paediatric-onset MS but not with monophasic acquired CNS demyelination

Genetic loci associated with adult onset-MS is also associated with an increased risk to MS in children. This has the potential to predict MS diagnosis in children who present with a once off acquired demyelinating syndrome.

From MSIF

Latest MS research news | 13 November 2013

Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations.

This study showed that the number of cases of LHON-MS fell in a range that could be predicted by the chance occurrence of MS and the genetic mutations known to cause LHON.

From MSIF

Latest MS research news | 13 November 2013

Detecting cognitive dysfunction in a busy multiple sclerosis clinical setting: a computer generated approach

A computerised battery of memory tests was used to detect memory problems in subjects with different types of MS. It can be successfully administered in 20 minutes and may have a potential role in a busy clinic setting.

From MSIF

Latest MS research news | 05 November 2013

Clinically meaningful performance benchmarks in MS: timed 25-foot walk and the real world

The Timed-25 Foot Walk (T25FW) measures walking function in MS. This study found a performance of ≥6 seconds and ≥8 seconds represents clinically meaningful benchmarks of MS progression.

From MSIF

Latest MS research news | 05 November 2013

Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus

This study looked at two risk alleles found in the TNFRSF1A locus that are associated with MS susceptibility.

From MSIF

Latest MS research news | 05 November 2013

Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in rats

Studies have shown inflammation in the outer covering of the brain in patients with secondary progressive MS. This study shows that certain molecules which promote inflammation are involved.

From MSIF

Latest MS research news | 29 October 2013

Quality of life outcomes with BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: The DEFINE study

This study reports the effects of BG-12 on measures of health-related quality of life (HRQoL) over two years of treatment in the Phase III DEFINE study population.

From MSIF

Latest MS research news | 29 October 2013

Sex as a determinant of relapse incidence and progressive course of multiple sclerosis

This study looked at the relationship between gender differences in the incidence of MS relapses as well as the relationship between sex and primary progressive disease course on a large international observatory cohort: the MSBase registry.

From MSIF

Latest MS research news | 29 October 2013

Effects of exercise on fitness and cognition in progressive MS: a randomised, controlled pilot trial

This pilot randomised-controlled trial looked at the potential benefit of standardised exercise as a therapeutic intervention in progressive MS.

From MSIF

Latest MS research news | 21 October 2013

Teriflunomide versus subcutaneous interferon beta-1a in patients with RRMS: a randomised, controlled phase 3 trial

Teriflunomide selectively and reversibly inhibits dihydro-orotate dehydrogenase (DHODH). DHODH is a mitochrondrial enzyme involved in pyrimidine synthesis required by ...

From MSIF
 

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