This cross-sectional study from Brazil looked at the inner retinal
layers in the macula using frequency domain optical coherence tomography
(fd-OCT), in five different groups-controls, neuromyelitis optica
(NMO), longitudinally extensive transverse myelitis (LETM), MS with a
history of optic neuritis (MS-ON) and MS without a history of optic
neuritis (MS non-ON).
From each of the OCT scans, they
calculated the thickness of the retinal nerve fiber layer (RNFL), the
combined retinal ganglion cell and inner plexiform layers (RGCL+) and
the inner nuclear layer (INL). Results from this study showed that the
NFL was significantly thinner than in controls for all patient groups.
The INL thickness was significantly thicker than in controls for the
patients with NMO and LETM, but not for those with MS-ON or MS non-ON.
INL thickening occurs in patients with NMO and LETM, therefore this may
be useful for differentiating between NMO and MS.
Authors: Fernandes DB, Raza AS, Nogueira RG
Source: Ophthalmology. 2012 Oct 17. [Epub ahead of print]
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