Gene expression analysis of relapsing-remitting, primary progressive and secondary progressive MS

This study from Denmark investigated if different MS subtypes would show differences in gene expression which may be linked to specific subsets of peripheral blood mononuclear cells (PBMCs). The researchers found that 380 genes were differently expressed in RRMS, PPMS, SPMS and healthy controls. They did not find any major differences between the subtypes of MS. In PPMS the genes which showed the most prominent expression were associated with the innate immune system pathways while in RRMS the genes were associated with the adaptive immune response. People with SPMS shared pathways with both PPMS and RRMS. The change in gene expression was mainly associated with B cells, CD 8+ T cells and monocytes. Therefore, this study demonstrated that there were differences in gene expression seen between healthy controls and people with MS but not between MS subgroups.

Authors: Ratzer R, Søndergaard H
Source: Mult Scler. 2013 Oct 1. [Epub ahead of print]

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