Imaging resting state brain function in MS

This review article from Italy looks at different clinical stages in MS patients using resting state functional MRI (fMRI), which they used to investigate intrinsic brain activity across the whole brain and to measure the degree of functional correlation between different cortical regions.

Overall, it is felt that alterations of functional connectivity patterns at rest seem to correlate with disability progression. This raises the question of whether resting state fMRI could be useful in clinical settings to classify disease state of individual MS patients, ultimately aiming to develop novel biomarkers to help in the diagnosis, prognosis and monitoring treatment. Further studies are needed to further evaluate this.

Authors: Filippi M, Agosta F, Spinelli EG

J Neurol. 2012 Oct 9. [Epub ahead of print]

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