Investigation of outer cortical magnetisation transfer ratio abnormalities
Diagnosis, monitoring and biomarkers:
This study group looked at the
magnetisation transfer ratio (MTR) to investigate outer cortical
abnormalities in MS patients. The study included 44 patients with
relapsing remitting MS, 25 secondary progressive MS (SPMS), 19 primary
progressive MS (PPMS) and 35 healthy control subjects.
data from the cortex was segmented and subdivided into outer and inner
bands, with the MTR values calculated for each band. The results showed
that the mean outer cortical MTR value was lower than the mean inner
cortical MTR value in all MS groups and controls.
researchers found that the outer cortical MTR was decreased in SPMS and
RRMS, but not in PPMS, compared to controls. Outer cortical MTR was
lower in SPMS than in PPMS and RRMS. The lower outer cortical MTR values
in SPMS patients are likely due to more extensive cortical pathology
(demyelination and neuronal loss), as seen in post-mortem studies of
SPMS patients. The lower MTR values seen in the inner cortical band in
healthy controls are likely to reflect differences in myelin content.
Authors: Samson RS, Cardoso MJ
Source: Mult Scler. 2014 Feb 19 [Epub ahead of print]
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