Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event

This study from the US looked at the association between serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) with CSF oligoclonal bands and two lesions on brain MRI. 

135 high risk patients with CIS enrolled in the Observational Study of Early Interferon β-1a Treatment in High Risk subjects after CIS (SET study). They obtained high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) pretreatment in addition to thyroid stimulating hormone, free thyroxine, 25-hydroxy vitamin D3, active smoking status and BMI. Clinical and MRI assessments were obtained within four months of the initial demyelinating event and at six, 12 and 24 months. 

Results from the study showed that LDL-C and TC were adversely associated with MRI measures of lesion activity over two years. The time to first relapse and the number of relapses were not associated with any of the lipid profile variables. The researchers did not find an association between LDL-C and TC with disability changes. Higher free thyroxine levels were associated with lower cumulative number of contrast-enhancing lesions. Higher TC was associated with a trend with lower baseline whole brain volume. Therefore, this study demonstrates the lipid profile variables, in particular LDL-C and TC, are associated with MRI lesion activity. 

Authors: Weinstock-Guttman B, Zivadinov R

Source: J Neurol Neurosurg Psychiatry. 2013 Apr 17. [Epub ahead of print]

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