Lobar distribution of cortical grey matter lesions in MS clinical subgroups

This study looked at the lobar distribution of grey matter lesions as well as their relationship to the clinical course in MS. The study included 30 people with MS using phase sensitive inversion recovery (PSIR) MRI sequences to detect the grey matter cortical lesions in the frontal, parietal, temporal, occipital and insular lobes. The grey matter lesions were divided into either purely grey matter lesions-intracortical (IC, only involving the cortex) or leucocortical (LC, mixed grey-white matter lesions). The researchers found that the mean number of cortical grey matter lesions was 7.7+/-5.1 in the frontal lobe, 7.4+/-5.8 in the temporal lobes, 5.1+/-3.6 in the parietal lobes, 0.9+/-1.7 in the occipital lobes and 2.1+/-1.8 in the insular regions. Overall a higher number of lesions were found in the frontal and temporal lobes in both people with relapsing remitting and progressive MS. Occipital lesions were not as common. This is in keeping with histopathological studies which demonstrate cortical lesions mainly in the fronto-temporal regions.

Authors: Sethi V, Yousry TA
Source: J Neurol Neurosurg Psychiatry. 2013 Nov;84(11):e2. doi: 10.1136/jnnp-2013-306573.188

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