Long-term outcome of paediatric-onset multiple sclerosis: a population-based study

This population based study from the UK looked at clinical features and accumulation of disability in paediatric-onset MS (<18 years) and compared it to a cohort of patients with adult-onset MS (AOMS).

111 (5.4%) paediatric-onset MS (POMS) patients were identified from a cohort of 2068. 2.7% had disease onset <16 years and 0.3% under the age of 10. Results showed no significant difference in sex ratio, familial recurrence, relapse rate, ethnicity or clinical symptoms at presentation. They found that patients with POMS took longer to reach disability milestones and to develop secondary progressive disease. Despite POMS taking longer to reach disability milestones, they do so at a younger age and are therefore considered to have a poorer prognosis. Interestingly, they did not identify evidence of more active disease in POMS compared to AOMS.

Authors: Harding KE, Liang K, Cossburn MD

Source: J Neurol Neurosurg Psychiatry. 2012 Nov 15. [Epub ahead of print]

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