Lower urinary tract symptoms and urodynamic dysfunction in clinically isolated syndromes suggestive of MS

Research into MS and quality of life:
The research group investigated the prevalence of urinary tract symptoms, their impact on quality of life measures and their association with functional urodynamic dysfunctions, in a group of 28 patients with clinically isolated syndrome.

Each patient enrolled in the study had a full neurological and urological visit, urodynamic tests and the MS quality of life (MSQoL-54) questionnaire. Results showed that 53.6% of CIS patients reported urinary symptoms, 46.7% reported irritative symptoms, 33.3% reported both irritative and obstructive symptoms, while 20% reported obstructive symptoms only.

57.1% of CIS patients had abnormalities on urodynamic studies and 17.9% of the CIS patients with abnormal urodynamic studies were asymptomatic. Patients with urinary symptoms had lower scores on specific quality of life domains. This study demonstrates the importance of identifying and adequately treating urinary symptoms at the early stages of MS.

Authors: Di Filippo M, Proietti S
Source: Eur J Neurol. 2014 Jan 28. doi: 10.1111/ene.12370. [Epub ahead of print]
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