This study reviews the role of oxidative stress in neurodegenerative
conditions, in particular MS. Recent data has highlighted the important
role of anti-oxidative pathways for tissue protection in
chronic-progressive MS, especially transcription factor nuclear factor
(erythroid-derived 2) related factor 2 (Nrf2).
Based on this,
novel therapies, like fumaric acid esters (FAE), which is a new oral
available treatment which has been tested in phase II/III trials,
demonstrate positive outcomes on both relapse rate and MRI markers. At
the cellular level, the application of fumaric acid esters enhances
neuronal survival and protects astrocytes against oxidative stress. The
use of fumaric acid esters involves direct modification of the inhibitor
of Nrf2, Kelch-like ECH-associated protein 1. Oxidative stress plays an
important role in the pathophysiology of MS and is a very promising
target for future therapies like fumeric acid esters.
Authors: Lee DH, Gold R, Linker RA
Source: Int J Mol Sci. 2012;13(9):11783-803. Epub 2012 Sep 18.
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