Multicontrast MR Imaging at 7T in MS: Highest Lesion Detection in Cortical Gray Matter with 3D-FLAIR

The researchers in this study looked prospectively at 37 MS patients, who underwent multicontrast 7T MR imaging including 2D-T2WI, 3D-T1WI, 3D-FLAIR and GM-specific 3D-DIR. The sensitivity of conventional MRI techniques to detect cortical lesions remains poor when compared with histopathologic studies. Grey matter abnormalities strongly explain cognitive and physical disability. Results showed that the 3D-FLAIR detected the highest number of total cortical grey matter lesions at 7T. The improved visibility of cortical abnormalities at DIR, seen at 1.5T and at 3T did not hold in the 7T dataset.

Authors: Kilsdonk ID, de Graaf WL, Lopez Soriano A

AJNR Am J Neuroradiol. 2012 Oct 4. [Epub ahead of print]

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