Neuro-ophthalmologic evaluation, quality of life, and functional disability in people with MS.

This study from Spain looked at the association between longitudinal changes in neuro-ophthalmologic measures, quality of life (QOL) and disability in people with MS, using optical coherence tomography (OCT), visual evoked potentials (VEP) and visual field examination.

The study included 45 people with relapsing-remitting MS who underwent MS Quality of Life Questionnaire (MEQOL-54) and EDSS, in addition to neuro-ophthalmologic examination including visual field testing, retinal nerve fibre layer (RNFL) measurements using Cirrus and Spectralis OCT and VEP.

Participants were re-evaluated at 12, 24 and 36 months. They found that RNFL thickness results at baseline were significantly different from those at 3 years; however, there was no difference in visual acuity, colour vision, visual fields and VEP. An increase in EDSS score was associated with a reduced MSQOL-54 score. People with a longer duration of MS had a lower MSQOL-54 score.

Authors: Garcia-Martin E, Rodriguez-Mena D

Source: Neurology. 2013 May 24. [Epub ahead of print]

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