No MRI evidence of cortical lesions in neuromyelitis optica

This collaborative imaging study aims to examine the presence of cortical lesions in neuromyelitis optica (NMO). The authors have used a double inversion recovery sequence for detection of cortical lesions which has now become a standard sequence for this purpose in studies of MS patients.

As well as 30 patients with NMO, 30 RRMS patients and 30 healthy controls were scanned. The authors report detection of cortical lesions using this imaging sequence in two thirds of MS patients but not in any NMO patients. The authors therefore suggest that grey matter imaging may be a useful investigation in cases where uncertainty over a diagnosis of MS vs NMO exists.

Calabrese M, Oh MS, Favaretto A, Rinaldi F, Poretto V, Alessio S, Lee BC, Yu KH, Ma HI, Perini P, Gallo P.

Neurology. 2012 Sep 19. [Epub ahead of print]

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