This collaborative imaging study aims to examine the presence of
cortical lesions in neuromyelitis optica (NMO). The authors have used a
double inversion recovery sequence for detection of cortical lesions
which has now become a standard sequence for this purpose in studies of
As well as 30 patients with NMO, 30 RRMS patients
and 30 healthy controls were scanned. The authors report detection of
cortical lesions using this imaging sequence in two thirds of MS
patients but not in any NMO patients. The authors therefore suggest that
grey matter imaging may be a useful investigation in cases where
uncertainty over a diagnosis of MS vs NMO exists.
Authors: Calabrese M, Oh MS, Favaretto A, Rinaldi F, Poretto V, Alessio S, Lee BC, Yu KH, Ma HI, Perini P, Gallo P.
Source: Neurology. 2012 Sep 19. [Epub ahead of print]
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