PET imaging of glucose metabolism, neuroinflammation and demyelination in the lysolecithin rat model for MS
Diagnosis, monitoring and biomarkers
This study investigated the potential role of positron-emission tomography (PET) imaging in monitoring local lesions using specific tracers -[11C]MeDAS, [11C]PK11195 and [18F]FDG, specific for myelin density, microglia activation and glucose metabolism respectively, in animal models.
Rats were injected with lysolecithin, which induces demyelination in the central nervous system, with associated local activation of micoglia and monocyte recruitment. PET imaging was carried out three days, one week and four weeks after injection.
Result showed that the PET imaging detected local demyelination induced by lysolecithin in the corpus callosum and striatum with [11C]MeDAS, while [11C]PK11195 detected associated microglial activation and monocyte recruitment. The [18F]FDG PET imaging was maintained in the demyelinating lesions.
Overall, this study demonstrated successful monitoring of myelin density, neuroinflammation and brain metabolism in small-MS like lesions. This may have a role in monitoring disease progression in MS patients in the future.
de Paula Faria D, de Vries EF
: Mult Scler. 2014 Mar 12. [Epub ahead of print]
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