Predictive value of one month retinal nerve fiber layer thinning for deficits at 6 months after acute optic neuritis

This prospective study looked at the retinal nerve fibre layer (RNFL) by optical coherence tomography (OCT) and scanning laser polarimetry (SLP). They determined the threshold field mean deviation in 25 people with acute optic neuritis over a 6 month period. They correlated the RNFL values including the amount of thinning at 1-month and correlated this with 6-month outcome.

Results demonstrated that baseline visual performance and RNFL values were similar for eyes grouped by 1 month RNFL thinning. Eyes with 1 month RNFL thinning had greater and significant RNFL thinning at 6 months. RNFL thinning by OCT and SLP at 1 month correlated with 6 month OCT and SLP RNFL thinning. Therefore, early RNFL loss at 1 month was predictive of RNFL thinning at 6 months. This demonstrates the importance of the 1 month for predicting the outcome of acute optic neuritis.   

Authors: Kupersmith MJ, Anderson S

Source: Mult Scler. 2013 May 22. [Epub ahead of print]

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