Reproduction and the risk of multiple sclerosis

In this study from Denmark, they looked at the age of first birth and number of births to see if this had an effect on this risk of developing MS, as the incidence of MS in Denmark has doubled in women since 1970 and it has essentially remained unchanged in men. The study included 1,403 patients with MS of both sexes, with clinical onset between 2000 and 2004. For each case, 25 controls were matched by sex, year of birth and residential municipality.

Results showed that more female cases than controls had no childbirths or fewer births before clinical onset, but only in the last five years preceding onset. Childbirth within five years before clinical onset reduced the risk of MS onset in women. Parental age at first childbirth had no effect on the risk of MS. Overall, this study did not suggest reversed causality between childbirth and MS.

Authors: Magyari M, Koch-Henriksen N, Pfleger CC,

Source: Mult Scler. 2013 Mar 18. [Epub ahead of print]

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