In this study from Canada, they demonstrate novel techniques for
quantifying MTR (magnetization transfer ratio), by identifying focal
areas of MTR decrease (MTR lesions) directly on paired MTR images. They
quantified MTR changes in both MTR lesions and Gd lesions, and
demonstrate the ability of these methods to assess the extent of
demyelination and remyelination in vivo. The technique was used on
subjects with rapidly progressing MS before and after treatment with
immunoablation and autologous stem cell transplant.
the study showed that subjects who improved clinically after treatment
showed significantly improved MTR recovery in lesions that were
recovering during treatment. Those that remained clinically stable after
treatment showed significantly poorer MTR recovery. The results from
this study, suggest the longitudinal measurement of MTR and cumulative
changes in MTR lesions may be an important technique for quantifying
treatment effects on remyelination in clinical trials.
Authors: Brown RA, Narayanan S, Arnold DL.
Source: Neuroimage. 2012 Oct 27 [Epub ahead of print]
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