In this study, researchers looked at the relationship between nonresponders (NR) and interleukin-17 (IL-17A) serum titres, as well as binding antibodies (BAbs) to interferon-β (IFN-β) therapy. IL-17A is a proinflammatory cytokine which is involved in the pathogenesis of MS.
From their cohort of 72 people with relapsing-remitting MS treated for at least 18 months with IFN-β, 37.5% were NR and had a significantly higher serum IL-17A level when compared to the responder group. Also, 26.4% were IL-17A positive and had a higher number of relapses in the 12 months previously, in addition to a higher Expanded Disability Status Scale (EDSS).
Authors: Balasa R, Bajko Z, Hutanu A
Source: Mult Scler. 2012 Dec 3. [Epub ahead of print]
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