The effect of vitamin D-related interventions on MS relapses: a meta-analysis

This meta-analysis looked at five studies published as of September 2012, resulting in a total of 129 people with MS treated with high-dose vitamin-D treated and 125 controls. Observational studies to date have demonstrated an association between lower vitamin D levels and higher risk of relapse in people with MS. This raises the question of the potential benefit of vitamin D supplementation in people with MS. Based on this, the key objective was to look at the effect of vitamin D interventions on the relative risk of relapses in MS.

The researchers found no significant association between high-dose vitamin D treatment and risk of MS relapse. As the studies reviewed had some methodological limitations, they recommend that further longer studies are warranted.

Authors: James E, Dobson R

Source: Mult Scler. 2013 May 22. [Epub ahead of print]

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