As multiple sclerosis (MS) has a female predominance, the effect of pregnancy has been evaluated in a number of studies. In this study the results from the Brazilian national database on pregnancy in MS are reported.
As in previous studies the relapse rate was found to be significantly decreased during pregnancy and higher after delivery. However, the postpartum relapse rate was lower than the year preceding conception. This may be related to the use of corticosteroids or immunoglobulin immediately after delivery for MS patients in Brazil.
69.7% of the women studied were exposed to drugs for at least some time during pregnancy. The rate of obstetric, neonatal, and perinatal complications was low.
Authors: Finkelsztejn A, Fragoso YD, Ferreira ML, Lana-Peixoto MA, Alves-Leon SV, Gomes S, Damasceno BP, Mendes MF, Salgado PR, Correa EC, Comini-Frota ER, Diniz DS, Gama PD, Kaimen-Maciel DR, Morales RR, Arruda WO, Grzesiuk AK, Khouri JM, Lopes JS, Rocha CF, Domingues R, Gonçalves MV, Lorenti MA, Parolin MK, Siquineli F, Tosta ED, Brooks JB, Gallina AS, Melges LD, Ruocco HH.
Source: Clin Neurol Neurosurg. 2010 Dec 13. [Epub ahead of print]
Read the abstract