Observational studies have suggested that vitamin D may reduce inflammation in relapsing-remitting MS, but this has not been clearly confirmed in randomized controlled trials.

To further explore the possible anti-inflammatory effects of vitamin D, investigators from Norway examined the effect of high-dose oral vitamin D (20,000IU/week) on eleven blood markers of inflammation in 68 people with RRMS.

While the oral supplement more than doubled the mean vitamin D level in the blood, it did not have a significant effect on inflammation when compared to the dummy drug.

These results do not confirm an association between increasing vitamin D levels in the blood and reduced inflammation in relapsing-remitting MS, as previously proposed by other studies.

However, the researchers cannot exclude that vitamin D3 supplementation may affect other relevant markers not measured in their trial.

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