MS is complex and can cause many different symptoms. Early MS may present itself as a history of vague symptoms, which may occur sporadically over a prolonged period of time and could often also be attributed to a number of other medical conditions. Invisible or subjective symptoms are often difficult to communicate to doctors and health professionals and it is not uncommon for a diagnosis to take several months, and frustratingly it can take even longer.

Even when a person shows a ‘classic’ pattern of MS-type symptoms, the symptoms must conform to agreed criteria (called the McDonald criteria) before a doctor or neurologist can diagnose clinically ‘definite’ MS.

In 2001, the International Panel on the Diagnosis of Multiple Sclerosis updated the criteria to include specific guidelines for using magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, and visual evoked potentials (EP) to speed up the diagnostic process.

There are a range of tests that can be used to find out if someone has MS or not, but there is no single test to diagnose MS which is conclusive on its own. The tests include:

Neurological examination

Your neurologist will ask you lots of questions about past symptoms and problems – this is known as ‘history taking’. It helps the neurologist get a better picture of you and can help identify any other problems that may explain current symptoms. A physical examination checks for changes or weaknesses in your eye movements, leg or hand coordination, balance, sensation, speech or reflexes. Whilst a neurologist may strongly suspect MS at this stage, a diagnosis won’t be given until other test results confirm MS.

Magnetic resonance imaging (MRI)

An MRI scanner uses a strong magnetic field to create a detailed image of the brain and spinal cord. It shows the exact location and size of any damage or scarring (lesions). To get the image of the brain and spinal cord, your will lie down and enter a small tunnel in the centre of the MRI scanner. The process can take between 20 and 60 minutes and is painless, but quite noisy.

Recently, powerful MRI techniques have been used to study inflammation and tissue damage in regions of the brain, for which conventional MRI techniques are not sensitive enough. Several of these non-conventional MRI techniques are being developed for use in the diagnosis of MS.

Evoked potentials

Evoked potential testing involves measuring the time it takes for the brain to receive messages from the eyes. The neurologist will place small electrodes on your head to monitor brain waves as visual stimuli are presented
on a screen. These electrodes measure tiny electrical impulses; they are not painful. If MS or a similar condition is active, this test can detect messages to and from the brain travelling more slowly than usual.

Lumbar puncture

During a lumbar puncture (or spinal tap), the neurologist inserts a needle into the space around the spinal cord, under local anaesthetic. A small sample of the fluid that flows around the brain and spinal cord, called ‘cerebrospinal fluid’, is taken out and tested for abnormalities that occur in MS. The fluid will be sent to the laboratories to be examined. In some cases the fluid pressure will also be measured. People commonly report headaches following a lumbar puncture. This is a recognised side effect and the neurologist can advise on how best to manage this.

Scientists are also identifying biological indicators, or ‘biomarkers’, in the blood or cerebrospinal fluid which can be used in the diagnosis or monitoring of the condition.


A man operates an MRI machine from a computer

MRI machine with operator. Photo: Robert van Willigenburg

A set of images from a Magnetic Resonance Imaging scan

A set of images from a Magnetic Resonance Imaging scan

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